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Latest Queensland research

4/28/2018

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HEALTH
Queensland Scientists Make Chronic Fatigue Syndrome Research Breakthrough
The condition has been linked to abnormal immune system cells.
 21/02/2017 4:07 PM AEDT | Updated 22/02/2017 8:51 AM AEDT
·         Luke CooperAssociate Editor, HuffPost Australia
 
SUPPLIED/NCNED
Researchers at Griffith University have made a Chronic Fatigue Syndrome breakthrough.
Queensland scientists have linked Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), to a dysfunctional immune system -- proving for the first time that the condition does stem from the body rather than the mind.
Researchers from Griffith University's National Centre for Neuroimmunology and Emerging Diseases (NCNED) told the Huffington Post Australia the breakthrough came through findings that showed abnormalities in immune cell receptors.
NCNED Co-Director, Professor Don Staines, said: "We have discovered and reported for the first time abnormalities of a certain receptor in immune cells of the body and hence it's likely to be in every cell in the body.
"What this is, is a defect in the receptor, which is a change in the gene transcription of these receptors, meaning they no longer function the way they should. What the receptors should do is to be able to transfer calcium from outside the cell to the inside."
According to Staines, the discovery of abnormal calcium immune system cells affects CFS sufferers in three main areas of the body where CFS-related pain usually occurs -- the brain and spinal cord, the pancreas and the stomach.
CFS is a debilitating, flu-like medical condition characterised not only by long-term fatigue but a whole host of other symptoms that limit a person's ability to carry out daily life.
There is no cure or effective treatment for chronic fatigue and a lack of understanding of the disease within the medical community has led to many sufferers being misdiagnosed.
"This is huge because for the first time we have documented the pathology in this illness. Up until now people have not really understood the illness," Staines said.
"This illness is very much under-diagnosed. We think about 1-2% of the population have this illness but it could be higher than that. This is a much more debilitating illness than people have realised."
Queensland Science Minister Leeanne Enoch said the findings are an important breakthrough in understanding CFS and helping those who suffer from it, in a statement released on Tuesday.
"This discovery is great news for all people living with [CFS] and the related [ME], as it confirms what people with these conditions have long known - that it is a 'real' illness - not a psychological issue," she said.
"The Griffith University breakthrough now means we have a target for therapeutic intervention, which is welcome news to the 250,000 Australians believed to be affected by CFS and ME."
Staines told HuffPost Australia researchers have now turned their sights towards creating a test that could identify dysfunctional cells in sufferers and developing future laboratory drug trials that could limit the cost of the condition on families.
"People can go for years of getting different tests and these are very substantial costs to the Australian economy, and also there are big costs for families who have to stay home or be a carer," he said.
"Now there's a lot of scope to develop, design and use different drugs. We can use different samples of drugs in what we call in-vitro, and then we can test them based on predictions that they would be a benefit in this condition."
The costs of CFS and ME diagnosis, treatment and management in Australia is estimated to be around $700 million annually, according to the Queensland Government's statement.
The findings come after NCNED received $1.6 million in research funding from the Queensland Government and a $4 million grant from the Stafford Fox Medical Research Foundation.
Staines believes this breakthrough is now a step forward for sufferers.
"We now know that this is a pronounced dysfunction of a very critical receptor and the critical role that this has, which causes severe problems to cells in the body." he said.
"We don't know that we can necessarily cure the illness but we can help people lead a normal life."
 
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Naviaux metabolomics

4/28/2018

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Metabolic features of chronic fatigue syndromeRobert K. Naviaux, Jane C. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson and Eric Gordon
PNAS 2016 September, 113 (37) E5472-E5480. https://doi.org/10.1073/pnas.1607571113
  1.     Edited by Ronald W. Davis, Stanford University School of Medicine, Stanford, CA, and approved July 13, 2016 (received for review May 11, 2016)
Significance
Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a characteristic chemical signature but also revealed an unexpected underlying biology. Metabolomics showed that chronic fatigue syndrome is a highly concerted hypometabolic response to environmental stress that traces to mitochondria and was similar to the classically studied developmental state of dauer. This discovery opens a fresh path for the rational development of new therapeutics and identifies metabolomics as a powerful tool to identify the chemical differences that contribute to health and disease.
Abstract
More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using these methods. Forty-five subjects (n = 22 men and 23 women) met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. Thirty-nine subjects (n = 18 men and 21 women) were age- and sex-matched normal controls. Males with CFS were 53 (±2.8) y old (mean ± SEM; range, 21–67 y). Females were 52 (±2.5) y old (range, 20–67 y). The Karnofsky performance scores were 62 (±3.2) for males and 54 (±3.3) for females. We targeted 612 metabolites in plasma from 63 biochemical pathways by hydrophilic interaction liquid chromatography, electrospray ionization, and tandem mass spectrometry in a single-injection method. Patients with CFS showed abnormalities in 20 metabolic pathways. Eighty percent of the diagnostic metabolites were decreased, consistent with a hypometabolic syndrome. Pathway abnormalities included sphingolipid, phospholipid, purine, cholesterol, microbiome, pyrroline-5-carboxylate, riboflavin, branch chain amino acid, peroxisomal, and mitochondrial metabolism. Area under the receiver operator characteristic curve analysis showed diagnostic accuracies of 94% [95% confidence interval (CI), 84–100%] in males using eight metabolites and 96% (95% CI, 86–100%) in females using 13 metabolites. Our data show that despite the heterogeneity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statistically robust, and chemically similar to the evolutionarily conserved persistence response to environmental stress known as dauer.

 

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Tai Chi and Fibromyalgia

4/28/2018

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Tai Chi Beats Aerobic Exercise for Fibromyalgia
Damian McNamara
March 22, 2018
 
Compared with aerobic exercise, the traditional martial art of tai chi is as good as, or better than, aerobic exercise, for improving the overall severity of fibromyalgia symptoms, new research shows.
Results of a 52-week single-blind trial showed that in addition to fibromyalgia symptom relief, tai chi was associated greater improvements in depression, anxiety, self-efficacy, and the mental component of the Short-Form Health Survey (SF-36) quality-of-life measure.
"Compared with aerobic exercise, the most commonly prescribed non-drug treatment, tai chi appears as effective as or better for managing fibromyalgia," the investigators, led by Chenchen Wang, MD, Tufts University School of Medicine in Boston, Massachusetts, write. "This mind-body approach may be considered a therapeutic option in the multidisciplinary management of fibromyalgia."
The study was published online March 21 in the BMJ.
 
Complex Disorder
A complex disorder, fibromyalgia is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and prominent physical and
psychological impairment, the investigators note. Estimates suggest it affects 2% to 4% of the general population aged 18 to 65 years.
 Aerobic exercise is recommended as a standard treatment for fibromyalgia, but many patients find it difficult to exercise because of fluctuations in symptoms. Some trials have suggested that tai chi alleviates pain and improves physical and mental health in patients with fibromyalgia but concluded that larger and more rigorous trials are needed to confirm the results.
In addition, the duration and frequency of tai chi required to achieve optimal benefit are unknown, as is its efficacy compared with that of aerobic exercise in this patient population.
To find out more, the investigators conducted a prospective, randomized, 52-week, single-blind, comparative effectiveness trial.
The study included 226 people with fibromyalgia who were randomly assigned to receive supervised aerobic exercise for 24 weeks, twice weekly (n = 75), or one of four Yang-style supervised tai chi interventions, 12 or 24 weeks once or twice weekly (n = 151).  Participants were followed for 52 weeks. Investigators report adherence was "rigorously" encouraged in person and by telephone.
The study's primary outcome was change in the revised Fibromyalgia Impact Questionnaire (FIQR) scores at 24 weeks compared with baseline. Secondary outcomes included changes of scores in patients' global assessment, anxiety, depression, self-efficacy, coping strategies, physical functional performance, functional limitation, sleep, and health-related quality of life as measured by the Short-Form Health Survey (SF-36).
The mean age of participants was 52 years, 92% were women, the racial/ethnic composition was diverse (61% white), and mean body mass index was 30 kg/m2. The average duration of body pain was 9 years.
Participants had poor health status at enrollment, indicated by an average SF-36 physical score that was about 2 standard deviations below that of the general US population.
Each supervised session lasted 1 hour, and all participants were encouraged to include at least 30 minutes of tai chi or aerobic exercise in their daily routine during the intervention period. The researchers also asked participants to continue their exercise routines for up to the 52-week follow-up.
Research staff blinded to group assignment measured body mass index, treatment expectations, adherence, safety, and physical performance on the 6-minute walk test.
People in the tai chi groups attended 62% of classes vs 40% of participants in the aerobic exercise group.
"Participants assigned to the mind-body therapy maintained higher and more consistent attendance than those assigned to aerobic exercise. Tai chi, which consists of a gentler, low impact meditative sequence of movements with minimal side effects, may be better embraced by patients with fibromyalgia in the long term," the authors write.
FIQR scores improved for participants in all groups compared to baseline at the 12-, 24- and 52-week evaluations. Participants in all five groups demonstrated a similar reduction in use of analgesics, antidepressants, muscle relaxants, and antiepileptic agents over time.
A total of 183 participants (81%) completed the 24-week evaluation. At this time point, improvement in FIQR scores in the combined tai chi groups was significantly greater than in the aerobic exercise group (P = .03).
The duration of tai chi mattered, with people in the 24-week groups reporting greater improvements in FIQR scores compared with those in the 12-week groups. The difference was statically significant (P = .007).
When the investigators looked at the frequency of tai chi, they found no significant difference in effectiveness at 24 weeks between those who participated in tai chi once a week and those participating twice a week, suggesting tai chi once a week may be sufficient to see the reported improvements. 
Secondary outcomes at 24 weeks that also significantly favored the tai chi groups included patient global assessment (P = .005), Hospital Anxiety and Depression Scale anxiety scores (P = .006), self-efficacy (P = .004), and coping strategies (P = .005).
A total of 154 adverse events (AEs) were reported in the study. This included 117 AEs among 115 participants assigned to tai chi and 37 among 75 participants in the aerobic exercise group. Most were minor musculoskeletal events, the authors noted, but 8 AEs in the tai chi group and 4 in the aerobic exercise group were considered related to the interventions.
Rethinking the Standard Treatment"It may be time to rethink what type of exercise is most effective for patients with fibromyalgia," Wang writes in an opinion piece accompanying the study.
"Despite the well-established benefits of aerobic exercise as a core standard treatment for fibromyalgia, patients in our trial had difficulty adhering to the aerobic exercise programme. This may not be surprising — many patients with fibromyalgia find performing and adhering to exercise programs hard. Complaints such as 'the floor is too hard,' 'I cannot stand this,' 'I'm too tired,' or 'I'm in too much pain' were common."
Three instructors taught tai chi in the study. The outcomes were consistent across these instructors, suggesting that the "classic Yang style tai chi can be deployed in other settings in a standardized manner for fibromyalgia," the authors write.
In another accompanying opinion piece, Amy Price, a trauma survivor with chronic pain and a former neurocognitive rehabilitation consultant, notes that her "balance was poor from brain and spinal damage, and I could only see the depressing future of being a patient with chronic pain. I didn't expect tai chi to work, but thought I'd give it a chance."
"Initially, I could only do ten minutes, three times a week, with constant supervision, because of memory and balance problems. Gradually, over about six weeks, my balance improved and this reduced anxiety and increased strength in my broken body," she writes. She would generally recommend tai chi for others with fibromyalgia but recommended patients discuss the option with their physician first, that they stop and speak up if they feel any pain, and that the quality of the instructor matters.
The National Institutes of Health National Center for Complementary and Integrative Health, the National Center for Research Resources, and the National Center for Advancing Translational Sciences funded the study. Wang has disclosed no relevant financial relationships. Price is The BMJ Patient Editor for Research and Evaluation and serves on the BMJ Patient Panel. She has disclosed no relevant financial relationships.
BMJ. Published online March 21, 2018. Abstract
 
 
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Chronic Fatigue Syndrome Linked to Low T3 Syndrome

4/28/2018

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​Miriam E Tucker  March 29, 2018
 
Some people with the condition known as chronic fatigue syndrome (CFS) have low circulating levels of the thyroid hormone triiodothyronine (T3) and normal levels of thyroid-stimulating hormone (TSH), new research shows. The results suggest these patients may be in a hypometabolic state, but one expert thinks the low levels are more likely a consequence, rather than a cause, of CFS.
The findings, based on 98 patients with CFS and 99 age- and sex-matched controls, were published online March 20 in Frontiers in Endocrinology by Begoña Ruiz-Núñez, a PhD student at the University of Groningen, the Netherlands, and colleagues.
Several CFS symptoms resemble those of hypothyroidism but without the marked increase in TSH. This is also the case, the authors point out, in the so-called low T3 syndrome. Low T3 syndrome, also known as euthyroid sick syndrome, is characterized by decreased serum T3 and/or thyroxin (T4) levels, increased reverse T3 (rT3), and no significant increase in TSH.
This low T3 syndrome might be in line with recent metabolomic studies that point to a hypometabolic state (Proc Natl Acad Sci U S A.2016;113:E5472-E5480), and if confirmed, T3 and iodide supplements may be indicated as treatments, say Núñez and colleagues.
But endocrinologist Willard H Dere, MD, professor of internal medicine at the University of Utah, Salt Lake City, isn't convinced.
"The limited data are consistent with what is seen in other inflammatory and chronic disease states. There is no current evidence that thyroxine or tri-iodothyronine replacement in those with low T3 syndrome is beneficial. Furthermore, in hypothyroid patients on thyroxine replacement, the use of tri-iodothyronine, along with L-thyroxine, is thought by some experts to be beneficial, but this view is not a consensus," he told Medscape Medical News.
Differences Seen in Thyroid Hormones, Inflammatory Markers
The patients were recruited from a single clinic in Amsterdam, and all had been diagnosed with CFS based on 1994 criteria. However, those criteria differ in several ways from more recent definitions of what is now termed myalgic encephalomyelitis (ME)/CFS, including those published by the US Institute of Medicine (IOM) in 2015.
Both definitions include disabling fatigue that lasts more than 6 months and does not improve with rest, and cognitive impairment. However, the IOM criteria place post-exertional malaise as central to the diagnosis, whereas it's not required in older definitions. Moreover, the IOM criteria don't require that other potentially fatiguing illnesses be ruled out before making the diagnosis, whereas the older definition does.
In the current study, the 21 men and 77 women with CFS had a mean age of 43 years and body mass index (BMI) of 22 kg/m2. The 23 men and 76 women who were control participants had a mean age of 39 years and BMI of 23 kg/m2, which were not significantly different from the CFS group.
Compared with controls, the CFS group had lower levels of free triiodothyronine (FT3), total T4 (TT4), total T3 (TT3), percent TT3, sum activity of peripheral deiodinases (SPINA-GD), and secretory capacity of the thyroid gland (SPINA-GT), as well as lower ratios of TT3/TT4, FT3/FT4, TT3/FT3, and TT4/FT4, and higher percent rT3 and rT3/TT3 ratio.
There were no differences between groups in other thyroid hormone parameters, notably TSH, FT4, rT3, and percent TT4.
FT3 levels below the reference range were more frequent in the CFS group (16/98) compared with controls (7/99; P = .035), with an odds ratio of 2.56 (95% CI, 1.00 - 6.54).
However, Dere commented, "The subset of patients with the low T3 syndrome is relatively small, and their laboratory values don't vary substantively from that of the control group. Overall, I think the probability of a low T3 syndrome causing ME/CFS is low."
In measures of metabolic inflammation, no significant differences were found in white blood count, high-sensitivity C-reactive protein (hsCRP), tryptophan/kynurenine ratio, or urinary isoprostanes, but the CFS group did have lower kynurenine and tryptophan levels than controls.
Ferritin was higher and HDL-cholesterol was lower in patients with CFS. Zonulin, a parameter of intestinal permeability, was also lower in patients with CFS compared with controls.
Measures of nutritional factors influencing thyroid function and inflammation that differed between the groups included 24-hour urinary iodine output, a proxy of iodine status, which was lower in patients with CFS. Plasma selenium was similar, but intracellular selenium was higher in patients with CFS. Vitamin D [25(OH)D] status of patients with CFS was higher, but 59% of patients with CFS and 83% of controls presented with 25(OH)D levels below the optimal cutoff of 80 nmol/L, Ruiz-Núñez and colleagues report.
In two sensitivity analyses that excluded patients with the highest levels of inflammatory markers, all the prior findings remained significant except FT3, which was no longer significantly lower in the CFS group.
Markers of Inflammation: Cause or Consequence?
Overall in both groups, FT3, TT3, TT4, and rT3 were positively related with hsCRP.
"The limited data from this study correlates other markers of inflammation with the presence of low T3 and high reverse T3, and are consistent with what is seen with other inflammatory and chronic disease states," Dere noted.
He added that the low T3 state "seems to be the result, not the cause, of a systemic or localized inflammatory or chronic disease state. During caloric deprivation, the fall in T3 is believed to be an adaptive response directed to saving energy and protein for enduring this acute stress. Thus one can speculate that with some chronic disorders, the diminished plasma T3 helps to preserve caloric expenditure."
Overall, Dere said he wouldn't change clinical practice based on these findings. "A serum TSH is a good screening test to rule out primary thyroidal disorders."
 
Front Endocrinol. Published March 20, 2018. 
Medscape Medical News © 2018 WebMD, LLC
 
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Drug Hoped To Treat CFS Causes Impaired Immune Function

4/28/2018

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Griffith Study Says:
Reports that a drug used to treat autoimmune diseases and cancer could also treat Chronic Fatigue Syndrome (CFS) have been refuted by a new Griffith University study.
To be published in BMC Pharmacology and Toxicology, the study by Griffith’s National Centre for Neuroimmunology and Emerging Diseases(NCNED) concluded that the use of Rituximab in CFS patients could incur problems with their immune cells and is not beneficial as a potential treatment.
The Natural Killer (NK) cells have vital functions in fighting viruses, bacteria and tumours.
“We found that these functions were significantly impaired when exposed to Rituximab in CFS patients,” says Scientific Co-Director of NCNED, Professor Sonya Marshall-Gradisnik.
CFS – sometimes known as ME (myalgic encephalomyelitis) – is a complex illness characterised by impaired memory and concentration, metabolic, cardiac, gut and immune dysfunction and debilitating muscle pain and fatigue on exertion (also known as neuroimmune exhaustion).
It is estimated that the prevalence rate of CFS/ME worldwide is between 1 and 2 per cent.
Related to the ion channels
The Gold Coast NCNED team has discovered the illness is related to problems in the ion channels that allow calcium into the body’s cells. Calcium is required by almost every cell in the human body and is vital in helping the immune system destroy a virus or infection.
The team has proven that patients with CFS/ME have lower levels of calcium coming into their cells, that their cells store less calcium and that this is the basis of their illness.
Professor Don Staines, Clinical Co-Director of NCNED, says: “These results are important as NK cells are already known to have impaired function in CFS patients, suggesting certain doses of Rituximab may not be beneficial for the treatment of this condition.”
“Undertaking an initial study has enabled us to secure additional research funding from the national competitive grants process from the Mason Foundation where we can now undertake a larger study using this drug in vitro to validate our novel findings,” says Professor Staines.
First author for these world-first scientific findings was PhD student, Ms Natalie Eaton.  She will be presenting the study at an NCNED-sponsored conference later this year.  The focus of the conference will be promoting greater understanding of pathology and pharmacothereapeutics for CFS, through a Research, Innovation, Discovery, Learning and Education (RIDLE) model.
Source: Press Release: Griffith University, March 27, 2018.
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Low dose naltrexone for chronic pain

4/28/2018

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Low-dose Naltrexone Explored as Option for Chronic Pain
Miriam E. Tucker
March 16, 2018
SALT LAKE CITY, UT — Low-dose naltrexone (LDN) holds promise for treating chronic pain associated with a wide range of conditions, including fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
In fact, pending further study, LDN might offer a low-cost, nonaddictive opioid alternative for patients with chronic pain, according to Jarred W. Younger, PhD, director of the Neuroinflammation, Pain and Fatigue Lab at the University of Alabama, Birmingham.
"Opioids work fast, but they may cause pain sensitivity when used long-term, so I think they should be used for only short periods of time. LDN lowers pain sensitivity over time, so may be a better choice for chronic pain," Younger told Medscape Medical News.
Naltrexone is an opiate antagonist currently available in a daily 50-mg tablet dose for the treatment of alcohol and opioid dependence. But in addition to opioid receptor antagonism, the drug also appears to exert anti-inflammatory effects via a separate mechanism targeting microglial cells.
Paradoxically, the dosage found to reduce pain is roughly one tenth the substance abuse treatment dose, around 4.5 mg per day. The low-dose version is not approved by the US Food and Drug Administration and must be specially compounded.
In studies of several known inflammatory conditions, including inflammatory bowel disease and multiple sclerosis, LDN reduced both self-reported pain and objective markers of inflammation and disease severity, Younger noted in a 2014 review article.
Evidence Supports LDN for Fibromyalgia, and Anecdotally for ME/CFS
At a 2-day summit held March 2 and 3, 2018, at the Bateman-Horne Center here in Salt Lake City, a panel of 13 clinicians who specialize in ME/CFS selected LDN as a top drug for that patient population, based on their clinical experience using it in their patients with ME/CFS who have hyperalgesia. The panel also placed LDN at the top of a wish list for randomized clinical trials of treatments for ME/CFS specifically.
There is currently no drug approved by the US Food and Drug Administration for ME/CFS, and treatment of the condition focuses on relief of symptoms including widespread pain. Many patients with ME/CFS also meet clinical criteria for fibromyalgia, for which LDN has shown benefit in several of Younger's studies.
Lucinda Bateman, MD, who directs the Bateman-Horne Center and chaired the ME/CFS summit, said she uses LDN frequently in her patients with fibromyalgia and those with ME/CFS for whom pain is a top complaint. "I'm totally convinced that in patients with pain amplification/hyperalgesia as their primary problem, it's great. It's as good as all the [approved fibromyalgia drugs], but cheaper."
However, she also noted, "The real unanswered question is, does LDN help cognition, fatigue, and other things related to neuroinflammation? We know that glial cells are involved in hyperalgesia, and we know LDN downregulates [microglia]. But that's not the same as downregulating everything about neuroinflammation."
Susan M. Levine, MD, an infectious disease and ME/CFS specialist in New York City, also prescribes LDN. "People think of it more for fibromyalgia, but it's definitely in our armamentarium for ME/CFS patients. I find it helps with both pain and sleep."
A typical protocol, Younger said, would be to start at 1.5 mg daily for 1 week, then titrate up to 3.0 mg for another week and then 4.5 mg daily. But as individual responses vary, it may take a bit of adjusting to find the right dose for a given patient. Some may respond better to 6.0 to 7.0 mg/day.
Levine explained that she starts at a much lower LDN dose, as low as 0.1 to 0.5 mg, as she is concerned about sensitivity in these patients.
Patients should be advised that it could take up to 2 months before they notice any changes with LDN, so they "should not give up too soon if they are not noticing beneficial effects right away," Younger noted.
Well-Tolerated, Lower Cost
Younger told Medscape Medical News that LDN is very well-tolerated in his studies, with the only common adverse effect being particularly vivid dreams in about 20% of patients. Smaller numbers have reported anxiety after taking LDN, or trouble falling asleep if they take it at bedtime.
"Everyone responds differently to medications, so patients and clinicians should track responses to any new medication carefully," he cautioned.
Although the low dosage of naltrexone used won't necessarily interact with opioid analgesics, care should be taken in combining the two, as naltrexone might block the effectiveness of hydrocodone and oxycodone.
Also, "There is also a small chance that LDN could interact with alcohol to make the person feel nauseated. After starting LDN, individuals should test alcohol before consuming a large amount," Younger advised.
As a generic medication, LDN is far less expensive than currently approved fibromyalgia drugs, at roughly $30 a month (including the cost of compounding) compared with approximately $500/month for Lyrica. In contrast, insurance doesn't currently cover LDN, as it's not yet approved for any indication.
Companies are currently working to secure US Food and Drug Administration approval for naltrexone in 1.0- and 4.5-mg versions. And in the United Kingdom, an entity called The LDN Research Trust is pushing for inclusion of LDN on the National Health Service's medical formulary list so it can be easily prescribed.
Meanwhile, Younger is hoping to conduct a clinical trial of LDN specifically for ME/CFS, but has not yet received grant money.
"So, as of now, we have no research data showing whether LDN is as effective in ME/CFS as it is in fibromyalgia. This trial is still a high priority for the lab and it needs to be conducted.... It is hard to determine from anecdotal reports whether the medication is truly beneficial. My hypothesis is that it will significantly help a good percentage of ME/CFS patients, but we cannot know for sure until a study is completed."
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Mast Cell Activation

4/28/2018

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Mast Cell Activation May Underlie 'Chronic Fatigue Syndrome'
Miriam E. Tucker
March 13, 2018
 
SALT LAKE CITY, UT — Mast cell activation syndrome (MCAS) may be an overlooked yet potentially treatable contributor to the symptoms of chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS), say physicians who specialize in ME/CFS and its manifestations.
The subject was discussed during a 2-day clinician summit held March 2 to 3, 2018, during which 13 panelists met to begin developing expert consensus guidance for primary care and specialist physicians for the management of the complex multisystem illness ME/CFS, and to recommend research priorities.
"ME/CFS is a descriptive diagnosis of a bunch of symptoms, but it says nothing about what's causing the symptoms, which is probably part of the reason it's so hard for it to get recognition. So, the question becomes, What other pathology is driving this illness and making the person feel so ill? I think mast cell activation is one of those drivers, whether cause, effect, or perpetuator, I don't know," internist David Kaufman, MD, who practices in Mountain View, California, told Medscape Medical News.
MCAS is a recently described collection of signs and symptoms involving several different organ systems, that, as with ME/CFS itself, do not typically cause abnormalities in routine laboratory or radiologic testing. Proposed diagnostic criteria were published in 2010 in the Journal of Allergy and Clinical Immunology.
Kaufman first learned about MCAS about 5 years ago from a patient who introduced him to the published work of mast cell expert Lawrence Afrin, MD. "I spoke to him and then I started looking for it, and the more I looked, the more I found it," Kaufman said, estimating that he has identified MCAS in roughly half his patients who meet ME/CFS criteria.
Indeed, summit panel member Charles W. Lapp, MD, who recently retired from his ME/CFS and fibromyalgia practice in Charlotte, North Carolina, told Medscape Medical News, "I see a lot of this. I think it's one of the many overlap syndromes that we've been missing for years."
Another panel member, New York City ME/CFS specialist Susan M. Levine, MD, also said she sees MCAS frequently. "I suspect 50% to 60% of ME/CFS patients have it. It's a very new concept."
In Levine's experience, MCAS often manifests in patients being unable to tolerate certain foods or medications. "If we can reduce the mast cell problem, we can facilitate taking other drugs to treat ME/CFS," she said. However, she also cautioned, "It's going to be a subset, not all ME/CFS patients."
Clinical Assessment and Laboratory Testing
As discussed at the summit, for patients who meet ME/CFS criteria, the next step is to drill down into individual patients' symptoms and address treatable abnormalities. Investigation for MCAS may yield such findings among those who exhibit episodic symptoms consistent with mast cell mediator release affecting two or more of the following areas:
  • Skin: urticaria, angioedema, flushing
  • Gastrointestinal: nausea, vomiting, diarrhea, abdominal cramping
  • Cardiovascular: hypotensive syncope or near syncope, tachycardia
  • Respiratory: wheezing
  • Naso-ocular: conjunctival injection, pruritus, nasal stuffiness
Symptoms can wax and wane over years and range from mild to severe/debilitating. It is important to ask about triggers, Kaufman advised. "The patient is usually aware of what makes them feel worse."
 
Routine laboratory assessments include complete blood count with differential, complete metabolic panel, magnesium, and prothrombin time/partial thromboplastin time.
More specific laboratory testing can be tricky, as the samples must be kept cold. These include serum tryptase, chromogranin A, plasma prostaglandin D2, histamine, heparin, a variety of random and 24-hour urinary prostaglandins, and urinary leukotriene E4.
For patients who have had a prior biopsy, the saved sample can be stained for mast cells.
Kaufman said that initially after he learned about MCAS, he would only run the laboratory tests in patients with suggestive clinical history, such as food sensitivities/triggers, rashes, hives, temperature intolerance, or chemical sensitivities. "But ultimately, I had patients [for whom] I couldn't figure out what was going on; I would check, and started finding positives in patients I wasn't suspicious of."
So, now he just tests for it in all his patients with ME/CFS. "It's bigger than allergy," he remarked.
Treatment May Ease Some ME/CFS SymptomsTreatment of MCAS involves trigger avoidance as possible; H1 receptor antagonists such as loratadine, cetirizine, or fexofenadine (up to double the usual doses); H2 histamine receptor antagonists including famotidine or ranitidine; and mast cell membrane-stabilizers such as cromolyn sodium. Slow-release vitamin C can also help in inhibiting mast cells.
Over-the-counter plant flavonoids such as quercetin also may be helpful, typically at high doses (up to 1000 mg three times daily). "There's a long list of medications that either quiet down mast cell activation or block the receptor," Kaufman noted.
But despite that, without controlled trials, it is difficult to determine the exact clinical effects of blocking mast cells, especially as these patients tend to be taking many other medications. And in the context of ME/CFS, the extent to which suppressing mast cell activity addresses the core symptoms of fatigue, postexertional malaise, orthostatic intolerance, and cognitive dysfunction is unclear.
Kaufman noted, "I think treatment clearly helps with the fatigue because they're not reacting to everything. It improves gastrointestinal symptoms, so they can eat better.... I have seen [postural orthostatic tachycardia syndrome] improve, but I have to say I also give meds for dysautonomia, so I can't be sure."
Lapp said that in his experience, "[Patients with ME/CFS] aren't cured, but do get better. [Blocking mast cell activity] gets rid of dizziness, fatigue, nausea, and light sensitivity."
Levine pointed out, "We're just at the beginning of identifying this patient subset and thinking what makes sense to try.... One thing that's sure is that the drugs are pretty safe," she said, adding that when it comes to working up patients with ME/CFS for MCAS, "There only seem to be good things that can happen."
Kaufman, Lapp, and Levine have disclosed no relevant financial relationships.
 
 
 
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Bateman Clinicians' Summit

4/28/2018

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Much Can Be Done to Ease 'Chronic Fatigue Syndrome' Symptoms
Miriam E. Tucker       March 12, 2018
 
SALT LAKE CITY, UT — The illness commonly known as chronic fatigue syndrome is complex and currently incurable, but clinicians can still do a great deal to manage symptoms and improve patients' quality of life, experts agree.
In a 2-day meeting held March 2 and 3, 2018, specialists in the condition, now termed myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), met to discuss their assessment and treatment approaches. The aim of the "summit," organized by Lucinda Bateman, MD, and held at her Bateman-Horne Center facility here, was to initiate development of expert consensus ME/CFS guidance for primary care and specialist clinicians, and to identify research priorities to address major knowledge gaps.
"One of the messages I'd like to send to physicians is not to have an all-or-nothing approach to this illness, but to break it down into its parts, and see what you can get hold of with the history, objective markers, and clinical intuition. And then, it's not unreasonable to try some things that are not harmful or expensive," Bateman told Medscape Medical News.
The 13 panelists, who hail from primary care, infectious disease, immunology, neurology, endocrinology, pediatrics, and integrative medicine, discussed and prioritized elements of history-taking, physical exam findings, diagnostic tests, and treatment approaches for each of the illness' major components. The core features include fatigue, impaired function, postexertional malaise, sleep dysregulation, neurocognitive impairment, and orthostatic intolerance; other commonly reported features are widespread pain, immune dysregulation, and infection.
Panel members focused on approaches they have found to be most helpful and that can be accomplished in primary care, as well as more advanced modalities that would be more feasible in specialty practices.
Assessing the Illness
The document the group produces will endorse the 2015 Institute of Medicine diagnostic criteria, which define ME/CFS as 6 months of unexplained fatigue with substantial functional impairment, postexertional malaise, unrefreshing sleep, and either cognitive dysfunction or orthostatic intolerance. The symptoms must be moderate to severe and present at least 50% of the time. (Five summit participants, including Bateman, were on the writing committee for that report, and three others served as reviewers for it.)
Assessing functional capacity is key, Bateman said. "It's an illness that impairs people's ability to function in their daily lives. Clinicians need to ask about function, and what happens when people exert themselves both physically and cognitively."
One revealing question is, "What would you be doing now if you weren't ill?" Typically, as opposed to depressed patients, those with ME/CFS will have a laundry list. "Our patients are trapped in bodies that don't work," Bateman said. "They're desperate to do more."
Laboratory tests such as complete blood count with differential, complete metabolic panel, erythrocyte sedimentation rate and C-reactive protein, antinuclear antibody, rheumatoid factor, lipid panel, thyroid-stimulating hormone, and celiac screen should all be performed to investigate symptoms, but are often unhelpful. (As reported previously by Medscape Medical News, evidence suggests that the inflammatory cytokines involved in ME/CFS are different from those that induce C-reactive protein.)
 
In contrast, assessments that often yield valuable information in patients with ME/CFS include evaluation for orthostatic intolerance and autonomic dysregulation (ideally via tilt-table, but also can be accomplished with the 10-minute "Lean" test), and laboratory tests for Lyme immunoglobulin G (IgG) and IgM; lymphocyte subsets; IgG subclasses; Epstein-Barr virus, including early antigen antibody; herpes viruses; urine or serum markers of mast cell activation syndrome; small intestinal bacterial overgrowth; and natural killer cell function (almost universally low in patients with ME/CFS).
Brain imaging with magnetic resonance imaging or electroencephalography may be indicated in patients who exhibit "brain fog," headaches, or other neurocognitive symptoms.
"A lot of the testing we do is the differential diagnosis, and we're looking for comorbid conditions, treatment targets, and subgroups, like people with [small intestinal bacterial overgrowth] or mast cell activation. In the clinical setting, we don't have to make sense of it all. We just have to identify it, and see if the patient responds to treatment," Bateman said.
Panel member Charles W. Lapp, MD, who recently retired from his ME/CFS and fibromyalgia practice in Charlotte, North Carolina, told Medscape Medical News, "We use most tests for exclusionary purposes. We don't want to miss something that's treatable."
But, he added, some tests are for conditions that often accompany ME/CFS and exacerbate the symptoms. For example, for patients with high Epstein-Barr virus early antigen antibody titer, "if we can reduce that viral load, it might make the patient feel better. We don't know if its treating ME/CFS per se, but it's reducing the perpetuators, and that might make a difference."
Treatments Aimed at Symptom Relief
There is currently no US Food and Drug Administration-approved drug for ME/CFS, so treatments need to be individualized and directed toward the patient's most troubling illness manifestations and symptoms.
Medications that were endorsed by a majority of the panel include low-dose naltrexone for patients with pain and cognitive dysfunction, low-dose beta blockers or fludrocortisone for those exhibiting orthostatic intolerance, and intravenous Ig for patients with a variety of immune dysfunction indications including low IgG or IgA or recurrent infections.
Also universally viewed as critical for primary management of ME/CFS is the concept of adaptive pacing. With it, patients learn to conserve their limited energy by carefully adapting their activity so as not to exceed their anaerobic thresholds and thereby precipitate a "crash." One helpful website to offer patients is the CFIDS & Fibromyalgia Self-Help Program website.
There was also some endorsement among panel members for, but less agreement about the optimal use of, interventions such as antivirals or antibiotics, methyl folate for patients with methylenetetrahydrofolate reductase mutations, and immune modulators for low natural killer cell activity and other identified immune dysfunctions.
In general, much of the approach involves thinking outside the box, and sometimes borrowing from other fields, Bateman said. For example, she points to data suggesting that amantadine may improve fatigue and cognition in multiple sclerosis. "There's no reason we can't give [patients with ME/CFS] a trial of amantadine. Just making these cross-connections is very helpful."
Panel to Call for Randomized Trials of Biological Treatments
Panel members are well aware that not only are the products they use not approved by the US Food and Drug Administration for ME/CFS, but many are supplements that aren't even regulated by the administration. Part of the summit's deliverables will be a call for addressing that deficiency via randomized controlled clinical trials, according to the organizers.
"Very few treatments have been rigorously studied in ME/CFS," summit comoderator Anthony Komaroff, MD, professor of medicine at Harvard Medical School in Cambridge, Massachusetts, told Medscape Medical News. "For one thing, with drugs that are off patent, it is hard to find funding to test off-label use. And with drugs still on patent, pharma needs some empirical evidence of benefit before investing in pursuing a new indication for use, and collecting such evidence takes money.... So clinicians are left to trying treatments that are unproven, but for which there is a plausible rationale for their use, and little chance of harm."
 
Notably missing from the recommended treatment list are cognitive behavioral therapy aimed at overcoming "false illness beliefs" and "graded exercise." (A trial published in 2011 suggested those interventions were helpful, but it has since been faulted by the ME/CFS community because of its patient selection criteria and methodological issues.) The summit panel voted unanimously to include a statement rejecting those modalities as inappropriate and potentially harmful.
What Does the Patient Need?In addition to treatments, patients with ME/CFS very often have other critical needs. Some will require disability verification, for which 2-day cardiopulmonary exercise testing may be necessary to prove impairment in function and postexertional malaise. Patients with ME/CFS will show distinct abnormalities on the second day of 2-day cardiopulmonary exercise testing, but several panelists said they believe that it's too taxing for patients to be used in routine clinical assessment.
Other patient needs may include disability parking permits, home healthcare, equipment such as canes or wheelchairs, and social services such as Meals on Wheels for those living alone.
Several panel members expressed concern about the future for patients who lack sufficient social support, and for adult bedbound patients being cared for by aging parents. One physician described a Munchausen case in which a healthy school-aged child was faking illness to stay home and care for her mother, who was disabled with the real illness ME/CFS.
Validating the Patient's ExperienceOf course, all of this requires that the clinician accept and communicate to the patient that ME/CFS is real, despite the lack of clarity about its etiology, Komaroff noted. "There is a literature of over 9000 publications that says this has a biological underpinning. It's not imaginary, and it's not fabrication."
He continued, "People don't understand how devastating it can be to be really sick and for people to not believe you. The personal invalidation that people with this illness have experienced...the spouse, the parent, the employer who at first are sympathetic, but when three doctors in a row say there's nothing wrong, patients begin to see their support systems in danger."
And, Komaroff added, "The importance of clinical validation to the patients, in my experience, has been enormous, even when you follow it by 'I'm going to do everything I can, but I can't promise that I'm going to be able to make you feel better.' "
Indeed, Bateman said of the panel's work, "I want to take the knowledge that we have and make it impossible for people to turn away from this disease."
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